Association of blood cell parameters of peripheral inflammation with cognitive function

Background Chronic peripheral inflammation is associated with cognitive decline and increased risk of dementia. Easily measured circulating blood cell parameters, including the neutrophil to lymphocyte ratio (NLR), red distribution width (RDW), mean platelet volume (MPV), reflect inflammation. We sought investigate cross-sectional association between these measures neuropsychological (NP) test performance in Framingham Heart Study (FHS) Offspring, Third-generation, Omni cohorts. Method identified FHS participants who attended an exam that included a complete count sample underwent NP testing within five years draw. Linear mixed effect models were used parameters (NLR, RDW, MPV) individual scores adjusting for age, sex, education, cohort, time draw testing, prevalent cardiovascular disease, APOE-ε4 genotype, C-reactive protein, accounting familial correlation using random effect. additionally tested interactions age (≥ 60 vs. < years) on associations reported separately by group when significant (P interaction ≤ 0.01). Result Among 3531 (mean 60.3 years, range 25 97 47% male), 80% had at least some college 22% carriers. observed higher NLR poorer visual reproductions – delayed recall, Trails B - A, Hooper organization test, assess memory, executive function, visuospatial abilities respectively (Table). There was also RDW digit symbol assessing function. different effects two groups metric function (i.e., A), where correlated decreased aged ≥ (n=1865). Conclusion as associates lower years. In younger individuals, chronic may have smaller